John (Scott Adkins) awakens from a coma to find that his
wife and daughter were brutally murdered in a home invasion. With the help of FBI Agent
Gorman (Rus Blackwell), the still amnesiac John identifies the
perpetrator as former Universal Soldier (UniSol)Luc Deveraux (Jean-Claude
Van Damme), now a wanted man. Meanwhile, a sleeper agent named Magnus
(Andrei "The Pit Bull" Arlovski), one of the cloned Next Generation
UniSols from Regeneration working undercover as a plumber, is
activated. Magnus reaches a brothel and kills all the women working
there and most of the patrons, a group of men with exceptional physical resistance.
His last adversary, a clone of UniSol Andrew Scott (Dolph Lundgren) and
Deveraux's former nemesis, negotiates Magnus and injects him with a serum that
frees him from government control. Magnus is introduced to a separatist group
led by Deveraux and Scott, who are taking in wayward UniSols to turn them
against the government that created them, thus establishing a new order ruled
by UniSols.
Determined to find Deveraux, John receives a call from a
soi-disant friend named Isaac urging the two to meet. Upon reaching his house,
he finds Isaac long dead, as well as evidence of Isaac's involvement with the
UniSol government program. A matchbox found on the scene leads John to a strip
club. There, he is recognized and sent off by a stripper named Sarah (Mariah
Bonner), whom however he cannot remember. John is assaulted by Magnus who
injects him with Scott's serum, but despite hallucinating about Deveraux, he is
not turned. John abducts Sarah and takes her to his apartment, where they are
attacked by Magnus again. Though in the confrontation John loses some phalanges,
they manage to escape. Sarah later tells John she remembers him working as a
truck driver and living in a riverside cabin, and that the two were
romantically involved.
Starting to call his own memories into question, John
requests a meeting with Agent Gorman. He learns from Gorman that Deveraux was
often seen at the docks from where John used to take shipments. John
goes to the docks, inspects the last unshipped cargo and meets with local
manager Ron Castellano (Dane Rhodes), who plays hidden camera footage for him
showing Isaac being brutally murdered by John himself.
As John and Sarah drive towards the cabin, they are once
more intercepted by Magnus, whom John finally dispatches. On that occasion,
John realizes he possesses superior strength, resistance and fighting
abilities, his severed fingers having regrown in the meantime. John and Sarah
reach the cabin to find it inhabited by an exact duplicate of John,
who reveals himself as the original with whom Sarah and Castellano had been in
contact in the past. The original John had been mind-controlled into hunting
down Deveraux, but was turned by him and sent to kill Isaac and other men
behind the UniSol program, until he met Sarah and deserted Deveraux. He then
tries to kill Sarah, but is shot dead by the other John, now suspecting himself
to be a UniSol sleeper agent.
By the river, a rogue UniSol takes John to the underground
bunker where the separatists have their headquarters. There, he is greeted by
Dr. Su (David Jensen), who reveals that John never had a family, having been
synthetically created merely a few weeks earlier. Dr. Su goes on telling that
the missing shipment from the docks contains the hardware that will allow
Deveraux to create clones. John accepts Dr. Su's offer to surgically sever his
emotional bond with the fake memories of his family, but the pain and
attachment to those memories drive John insane. He kills every UniSol in his
path, culminating with Andrew Scott in a one-on-one confrontation. John then
reaches Deveraux himself and a fight ensues, with Deveraux eventually gaining
the upper hand. Realizing that the cycle of sending clones of John against him
is destined to repeat, and seeing John as a worthy successor who could turn the
tide of the rebellion, Deveraux gives in to John, who kills him with a machete.
Some time later, John meets with Agent Gorman again. Gorman
admits to his involvement with the UniSol program, and that he had purposefully
put an unaware John on Deveraux's trail. Gorman ascribes John's success to the
attachment to family he was designed with, as opposed to the patriotism implanted
in his predecessors. John kills Gorman, then three UniSols and a clone of
Gorman emerge from John's van. The clone leaves in the car of the original Gorman,
hinting that John has acquired the cloning equipment and taken over the
separatist group, now determined to infiltrate the government which he holds
responsible for his pain. The film ends with John driving his car as he
pictures flashbacks of him with his family.
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